                         SEQUENCE LISTING

<110>  Chemical & Biopharmaceutical Laboratories of Patras SA
 
<120>  Solid phase peptide synthesis via side chain attachment

<130>  P102129PCT

<140>  PCT/IB2013/051544
<141>  2013-02-26

<150>  US61/581,503
<151>  2011-12-29

<160>  42    

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic lanreotide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is D-2-naphthylalanine

<220>
<221>  DISULFID
<222>  (2)..(6)

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is D-tryptophan

<400>  1

Xaa Cys Tyr Xaa Lys Val Cys Thr 
1               5               


<210>  2
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic human insulin B-chain

<400>  2

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr 
            20                  25                  30  


<210>  3
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  3

Phe Val Asn Gln His Leu Cys Gly 
1               5               


<210>  4
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  4

Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe 
1               5                   10                  15      


Phe Tyr Thr Pro Lys Thr 
            20          


<210>  5
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic salmon calcitonin

<400>  5

Cys Ser Asn Leu Ser Thr Cys Val Leu Gly Lys Leu Ser Gln Glu Leu 
1               5                   10                  15      


His Lys Leu Gln Thr Tyr Pro Arg Thr Asn Thr Gly Ser Gly Thr Pro 
            20                  25                  30          


<210>  6
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic salmon calcitonin

<400>  6

Cys Ser Asn Leu Ser Thr Cys Val Leu Gly 
1               5                   10  


<210>  7
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic salmon calcitonin

<400>  7

Lys Leu Ser Gln Glu Leu His Lys Leu Gln Thr Tyr Pro Arg Thr Asn 
1               5                   10                  15      


Thr Gly Ser Gly Thr Pro 
            20          


<210>  8
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic octreotide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is D-cysteine

<220>
<221>  DISULFID
<222>  (1)..(7)

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is D-tryptophan

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is L-threoninol

<400>  8

Xaa Phe Xaa Lys Phe Thr Cys Xaa 
1               5               


<210>  9
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic exenatide

<400>  9

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  10
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic exenatide 1-11

<400>  10

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser 
1               5                   10      


<210>  11
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic exenatide 12-39

<400>  11

Lys Gln Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys 
1               5                   10                  15      


Asn Gly Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser 
            20                  25              


<210>  12
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic exenatide 1-13

<400>  12

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln 
1               5                   10              


<210>  13
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic exenatide 14-39

<400>  13

Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly 
1               5                   10                  15      


Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser 
            20                  25      


<210>  14
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ACTH 1-24

<400>  14

Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val Gly Lys Lys 
1               5                   10                  15      


Arg Arg Pro Val Lys Val Tyr Pro 
            20                  


<210>  15
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ACTH 1-10

<400>  15

Ser Tyr Ser Met Glu His Phe Arg Trp Gly 
1               5                   10  


<210>  16
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ACTH 11-24

<400>  16

Lys Pro Val Gly Lys Lys Arg Arg Pro Val Lys Val Tyr Pro 
1               5                   10                  


<210>  17
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pramlintide

<400>  17

Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu 
1               5                   10                  15      


Val His Ser Ser Asn Asn Phe Gly Pro Ile Leu Pro Pro Thr Asn Val 
            20                  25                  30          


Gly Ser Asn Thr Tyr 
        35          


<210>  18
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pramlintide 1-10

<400>  18

Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln 
1               5                   10  


<210>  19
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pramlintide 1-10

<400>  19

Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln 
1               5                   10  


<210>  20
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pramlintide 1-10

<400>  20

Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln 
1               5                   10  


<210>  21
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pramlintide

<400>  21

Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln 
1               5                   10  


<210>  22
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pramlintide 11-37

<400>  22

Arg Leu Ala Asn Phe Leu Val His Ser Ser Asn Asn Phe Gly Pro Ile 
1               5                   10                  15      


Leu Pro Pro Thr Asn Val Gly Ser Asn Thr Tyr 
            20                  25          


<210>  23
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pramlintide 12-37

<400>  23

Leu Ala Asn Phe Leu Val His Ser Ser Asn Asn Phe Gly Pro Ile Leu 
1               5                   10                  15      


Pro Pro Thr Asn Val Gly Ser Asn Thr Tyr 
            20                  25      


<210>  24
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pramlintide 14-37

<400>  24

Asn Phe Leu Val His Ser Ser Asn Asn Phe Gly Pro Ile Leu Pro Pro 
1               5                   10                  15      


Thr Asn Val Gly Ser Asn Thr Tyr 
            20                  


<210>  25
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic bivalirudin


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is D-leucine

<400>  25

Xaa Pro Arg Pro Gly Gly Gly Gly Asn Gly Asp Phe Glu Glu Ile Pro 
1               5                   10                  15      


Glu Glu Tyr Leu 
            20  


<210>  26
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic bivalirudin 1-10


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is D-leucine

<400>  26

Xaa Pro Arg Pro Gly Gly Gly Gly Asn Gly 
1               5                   10  


<210>  27
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sythetic octreotide


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is D-tryptophan

<400>  27

Phe Cys Phe Xaa Lys Phe Thr Cys 
1               5               


<210>  28
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic exenatide 13-39

<400>  28

Gln Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn 
1               5                   10                  15      


Gly Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser 
            20                  25          


<210>  29
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic exenatide 1-12

<400>  29

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys 
1               5                   10          


<210>  30
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic bivalirudin 11-20

<400>  30

Asp Phe Glu Glu Ile Pro Glu Glu Tyr Leu 
1               5                   10  


<210>  31
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic bivalirudin 1-10

<400>  31

Phe Pro Arg Pro Gly Gly Gly Gly Asn Gly 
1               5                   10  


<210>  32
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic bivalirudin

<400>  32

Phe Pro Arg Pro Gly Gly Gly Gly Asn Gly Asp Phe Glu Glu Ile Pro 
1               5                   10                  15      


Glu Glu Tyr Leu 
            20  


<210>  33
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic exenatide 15-39

<400>  33

Glu Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly 
1               5                   10                  15      


Pro Ser Ser Gly Ala Pro Pro Pro Ser 
            20                  25  


<210>  34
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pramlintide 10-37

<400>  34

Gln Arg Leu Ala Asn Phe Leu Val His Ser Ser Asn Asn Phe Gly Pro 
1               5                   10                  15      


Ile Leu Pro Pro Thr Asn Val Gly Ser Asn Thr Tyr 
            20                  25              


<210>  35
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pramlintide 13-37

<400>  35

Ala Asn Phe Leu Val His Ser Ser Asn Asn Phe Gly Pro Ile Leu Pro 
1               5                   10                  15      


Pro Thr Asn Val Gly Ser Asn Thr Tyr 
            20                  25  


<210>  36
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pramlintide 14-37

<400>  36

Asn Phe Leu Val His Ser Ser Asn Asn Phe Gly Pro Ile Leu Pro Pro 
1               5                   10                  15      


Thr Asn Val Gly Ser Asn Thr Tyr 
            20                  


<210>  37
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pramlintide 1-13

<400>  37

Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala 
1               5                   10              


<210>  38
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pramlintide 1-11

<400>  38

Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg 
1               5                   10      


<210>  39
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pramlintide 1-10

<400>  39

Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln 
1               5                   10  


<210>  40
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pramlintide 1-9

<400>  40

Lys Cys Asn Thr Ala Thr Cys Ala Thr 
1               5                   


<210>  41
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic exenatide 1-14

<400>  41

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met 
1               5                   10                  


<210>  42
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic exenatide 1-15

<400>  42

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu 
1               5                   10                  15  


